The phage displayed depolymerase activity and the subsequent genome analysis revealed the presence of a pectate lyase domain in its tail spike protein. In this study, a novel Proteus bacteriophage (vB_PmiS_PM-CJR) was isolated from an environmental sample and fully characterized. Bacteriophages and their enzymes have recently become investigated as alternative treatment options. The Proteus biofilms reduce efficiency of antibiotic-based treatment, which in turn increases the risk of antibiotic resistance development. mirabilis one of the leading causes of catheter-associated urinary tract infections. 1987, 169, 1509–1515.The adherence of Proteus mirabilis to the surface of urinary catheters leads to colonization and eventual blockage of the catheter lumen by unique crystalline biofilms produced by these opportunistic pathogens, making P. The secreted hemolysins of Proteus mirabilis, Proteus vulgaris, and Morganella morganii are genetically related to each other and to the alpha-hemolysin of Escherichia coli. A new method for determining the minimum inhibitory concentration of essential oils. Instability of protease (gelatinase) trait in Proteus mirabilis. Study of the structural changes on the antimicrobial activity of -bicyclics. Comparison of antimicrobial properties of monoterpenes and their carbonylated products. Inhibitory effect of some medicinal plants from Iran on swarming motility of Proteus rods. Screening of antibacterial activities of twenty-one oxygenated monoterpenes. Essential oils: their antibacterial properties and potential applications in foods: a review. Screening of some Palestinian medicinal plants for antibacterial activity. Antimicrobial activity of essential oils and other plant extracts. Mechanisms of antibacterial action of three monoterpenes. Inhibition of swarming and virulence factor expression in Proteus mirabilis by resveratrol. Modulation of swarming and virulence by fatty acids through the RsbA protein in Proteus mirabilis. Characterization of p-nitrophenylglycerol-resistant Proteus mirabilis super-swarming mutants. Inhibition of virulence factor expression ad swarming differentiation in Proteus mirabilis by p-nitrophenylglycerol. Abolition of swarming of Proteus by p-nitrophenyl glycerin: general properties. A medium to suppress the swarming of Proteus species. ZapA, the IgA-degradin metalloprotease of Proteus mirabilis, is a virulence factor expressed specifically in swarmer cells. Construction of a flagellum negative mutant of Proteus mirabilis: effect on internalization by human renal epithelial cells and virulence in a mouse model of ascending urinary tract infection. Swarming-coupled expression of the Proteus mirabilis hpmBA haemolysin operon. Potential virulence factors of Proteus bacilli. Molecular analysis of a metalloprotease from Proteus mirabilis. Swarmer cell differentiation in Proteus mirabilis. Evidence that putrescine acts as an extracellular signal required for swarming in Proteus mirabilis. Proteus morgani is less frequently associated with urinary tract infections than Proteus mirabilis- an explanation. Swarming and pathogenicity of Proteus mirabilis in the urinary tract. This work was supported by grants from the CNPq, CAPES, and FAPERGS. Four of them (citronellol, geraniol, α-terpineol, and terpinene-4-ol) are oxygenated compounds with hydroxyl groups, one is a cyclized monoterpenes alcohol (1,8-cineol), and three are monoterpene esters (citronellal, citral and pulegone). The eight compounds that effectively inhibit swarming were oxygenated monoterpenes. The reduction of the number of concentric rings and ring width are first indicatives of the interference of sub-inhibitory concentrations of terpenoids on swimming/swarming cell differentiation and swarming cell motility. Swarming inhibition was evidenced by a reduction on colony diameter, the number of concentric rings, and ring width ( Table 1 and Figure 1). These experiments showed that eight out of 17 compounds tested inhibited swarming significantly ( Table 1). mirabilis swarming behavior, LB swarming agar plates containing 1/10 MIC concentration of each compound were seeded with a drop (5 μL) of a stationary culture of wild-type L68 strain. To evaluate the effect of the monoterpenes on P.
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